000			03745nam a2200337Ia 4500
001			CRC0KE11800PDF
003			FlBoTFG
005			20171224123744.0
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008			111024s2012 fluadf sb 001 0 eng d
020			_a9781439839140 (ebook : PDF)
040			_aFlBoTFG _cFlBoTFG
090			_aQP551 _b.T44 2012
092			_a612.01575 _bT411
245	0	0	_aThermostable proteins _h[electronic resource] : _bstructural stability and design / _c[edited by] Srikanta Sen, Lennart Nilsson.
260			_aBoca Raton : _bCRC Press, _c2012.
300			_axii, 159, [16] p. of plates : _bill. (some col.).
504			_aIncludes bibliographical references and index.
505	0		_ach. 1. Delineation of the conformational thermostability of hyperthermophilic proteins based on structural and biophysical analyses / Atsushi Mukaiyama and Kazufumi Takano -- ch. 2. Role of packing, hydration, and fluctuations on thermostability / Fabio Sterpone and Simone Melchionna -- ch. 3. Analyzing protein rigidity for understanding and improving thermal adaptation / Doris L. Klein, Sebastian Radestock, and Holger Gohlke -- ch. 4. Thermostable subtilases (subtilisin-like serine proteinases) / Magn�us M. Kristj�ansson -- ch. 5. Combined computational and experimental approaches to sequence-based design of protein thermal stability / Julie C. Mitchell ... [et al.] -- ch. 6. Designing thermophilic proteins : a structure-based computational approach / Sohini Basu and Srikanta S
520			_a"Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of "thermophilic life forms" at the molecular level with an emphasis on design strategies.The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: computing and simulation methods in current and future thermostability research, especially in nonempirical situations, how rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications. The state of knowledge concerning structure function relations and the origins of their structural stability. Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures. Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities folding, unfolding, and misfolding essential to biological function"--Provided by publish
530			_aAlso available in print editi
538			_aMode of access: World Wide W
650			_aProteins _xConformati
650			_aProtei
655			_aElectronic books. _2l
700			_aSen, Srikan
700			_aNilsson, Lennart, _d1952 Nov.
776			_z9781439839133 (hardcover : alk. pap
856			_uhttp://marc.crcnetbase.com/isbn/9781439839140 _qapplication/PDF _zDistributed by publisher. Purchase or institutional license may be required for acce
999			_c15685 _d15685