000			02864nam a2200385Ii 4500
001			CRC0KE13583PDF
003			FlBoTFG
005			20171224123200.0
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007			cr||||
008			131227t20142014fluad ob 001 0 eng d
020			_a9781439874462 (ebook : PDF)
040			_aFlBoTFG _beng _cFlBoTFG _erda
090			_aRM170 _b.N66 2014
092			_a615.6 _bG797
245	0	0	_aNon-clinical vascular infusion technology / _cedited by Owen P. Green and Guy Healing.
264		1	_aBoca Raton : _bTaylor & Francis, _c[2014]
264		4	_c�201
300			_a1 online resource : _btext file, PD
336			_atext _2rdaconten
337			_acomputer _2rdamedi
338			_aonline resource _2rdacarrie
504			_aIncludes bibliographical references and index
505			_aVolume 1. The science -- volume 2. The techniques
520			_aPreface: "There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed"--Provided by publisher
530			_aAlso available in print format
650			_aDrugs _xTesting
650			_aIntravenous therapy
650			_aAnimal models in research
655			_aElectronic books. _2lcs
700			_aGreen, Owen P., _eeditor
700			_aHealing, Guy, _d1961- _eeditor
776			_iPrint version: _z9781439874455 _z9781439874493 (hardback : alk. paper
856			_uhttp://marc.crcnetbase.com/isbn/9781439874462 _qapplication/PDF _zDistributed by publisher. Purchase or institutional license may be required for access
999			_c14391 _d14391