000			06324cam a2200865 i 4500
001			ocn869847755
003			OCoLC
005			20171224114538.0
006			m o d
007			cr |||||||||||
008			140127s2014 iau ob 001 0 eng
010			_a 2014003283
040			_aDLC _beng _erda _cDLC _dYDX _dN$T _dYDXCP _dE7B _dCUS _dDG1 _dOCLCF _dCDX _dRECBK _dCOO _dEBLCP _dDEBBG
019			_a927509063
020			_a9781118847015 (ePub)
020			_a1118847016 (ePub)
020			_a9781118846940 (Adobe PDF)
020			_a111884694X (Adobe PDF)
020			_z9781118125656 (hardback)
020			_a9781118847237 (electronic bk.)
020			_a1118847237 (electronic bk.)
020			_a1118125657
020			_a9781118125656
029	1		_aNZ1 _b15581391
029	1		_aCHVBK _b325939896
029	1		_aCHBIS _b010259650
029	1		_aNZ1 _b15906859
029	1		_aGBVCP _b821064541
029	1		_aAU@ _b000058366570
029	1		_aDEBBG _bBV043396525
035			_a(OCoLC)869847755 _z(OCoLC)927509063
042			_apcc
050	0	0	_aQP551
072		7	_aSCI _x056000 _2bisacsh
082	0	0	_a571.6/58 _223
084			_aSCI017000 _2bisacsh
049			_aMAIN
245	0	0	_aRibosome-inactivating proteins : _bbiology and applications / _cedited by Fiorenzo Stirpe, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Bologna, Italy, Douglas A. Lappi, Advanced Targeting Systems, Inc., San Diego, California, USA.
264		1	_aAmes, Iowa : _bWiley, _c2014.
300			_a1 online resource.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
520			_a"This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"-- _cProvided by publisher.
520			_a"Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"-- _cProvided by publisher.
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record and CIP data provided by publisher.
505	0		_a""Title page""; ""Copyright page""; ""Contributors""; ""Preface""; ""1 Introduction and History""; ""Introduction""; ""Identification and Distribution in Nature""; ""Mechanism of Action""; ""Effects on Cells and Animals""; ""Role in Nature""; ""Practical Applications""; ""Bioweapons""; ""Future Challenges""; ""References""; ""2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily""; ""Introduction""; ""How to Investigate the Distribution of Proteins with an N-glycosidase Domain?""; ""Conclusions""; ""Acknowledgments""
505	8		_a""Introduction""""Family Sambuceae""; ""Type 2 RIPs from Other families""; ""Uses of nontoxic type 2 RIPs""; ""Concluding remarks""; ""Acknowledgment""; ""References""; ""6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins""; ""Introduction""; ""Cell Surface Events""; ""Endosome to TGN Sorting""; ""From the Golgi to the ER""; ""Reductive Separation and Destabilization of the Holotoxin Subunits""; ""Dislocation Across the ER Membrane""; ""Cytosolic Post-dislocation Events that Restore Catalytic Activity""; ""Concluding Remarks""; ""Acknowledgements""; ""References""
505	8		_a""7 Shiga Toxins""""Introduction""; ""Purification of Shiga Toxins""; ""Structure and Mechanism of Action of Shiga Toxins""; ""Role of Shiga Toxins in the Pathogenesis of HUS""; ""The 2011 German STEC Outbreak""; ""References""; ""8 The Structure and Action of Ribosome-inactivating Proteins""; ""Introduction""; ""Acknowledgments""; ""References""; ""9 Updated Model of the Molecular Evolution of RIP Genes""; ""Introduction""; ""Important Issues to be Considered in View of the Evolution of RIP Genes""
505	8		_a""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data""""New Insights in the Overall Phylogeny of Plant RIPs""; ""An Updated Model of the Molecular Evolution of the Plant RIP Gene Family""; ""What is the Evolutionary Link Between Plant and Non-Plant RIPs?""; ""Conclusions""; ""References""; ""10 Enzymology of the Ribosome-inactivating Proteins""; ""Introduction""; ""Ricin as RNA N-glycosidase""; ""Role of SRL in Ribosomes""; ""Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes""; ""Action of RIPs on DNA""
650		0	_aProteins _xSynthesis.
650		0	_aRibosomes _xStructure.
650		7	_aSCIENCE / Life Sciences / Cytology. _2bisacsh
650		2	_aProtein Biosynthesis.
650		2	_aRibosomes.
650		7	_aProteins _xSynthesis. _2fast _0(OCoLC)fst01079764
650		7	_aRibosomes _xStructure. _2fast _0(OCoLC)fst01097321
650		4	_aSCIENCE _xLife Sciences _xCytology.
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aStirpe, Fiorenzo, _eeditor of compilation.
700	1		_aLappi, Douglas A., _eeditor of compilation.
776	0	8	_iPrint version: _tRibosome-inactivating proteins _dAmes, Iowa : John Wiley & Sons Inc., 2014 _z9781118125656 _w(DLC) 2014002677
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118847237 _zWiley Online Library
938			_aEBSCOhost _bEBSC _n761020
938			_aYBP Library Services _bYANK _n11778616
938			_aebrary _bEBRY _nebr10862633
938			_aCoutts Information Services _bCOUT _n28220867
938			_aYBP Library Services _bYANK _n11225979
938			_aRecorded Books, LLC _bRECE _nrbeEB00436841
938			_aYBP Library Services _bYANK _n12673461
938			_aEBL - Ebook Library _bEBLB _nEBL4039221
994			_a92 _bDG1
999			_c13277 _d13277