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| 001 | ocn828743731 | ||
| 003 | OCoLC | ||
| 005 | 20171224114218.0 | ||
| 006 | m o d | ||
| 007 | cr cn||||||||| | ||
| 008 | 130211s2013 gw a ob 001 0 eng d | ||
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_a9783527648238 _q(e-book) |
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| 020 | _a9783527648207 | ||
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| 020 | _z9783527331079 | ||
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_aQP551.5 _b.P76 2013eb |
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_a615.19 _223 |
| 049 | _aMAIN | ||
| 245 | 0 | 0 |
_aProtein-protein interactions in drug discovery / _cedited by Alexander Dömling. |
| 260 |
_aWeinheim : _bWiley-VCH, _c2013. |
||
| 300 |
_a1 online resource (xxi, 314 pages) : _billustrations. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 |
_aMethods and principles in medicinal chemistry ; _vv. 56 |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aProtein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry of anchor residues to disrupt protein interactions / Carlos J Camacho, David R Koes, Alexander S Dömling -- SH3 domains as drug targets / James Luccarelli, Sam Thompson, Andrew D Hamilton -- p53/MDM2 antagonists: towards nongenotoxic anticancer treatments / Kareem Khoury, Tad A Holak, Alexander Dömling -- Inhibition of LFA-1/ICAM interaction for the treatment of autoimmune diseases / Kevin M Guckian, Daniel M Scott -- The PIF pocket of AGC kinases: a target site for allosteric modulators and protein-protein interaction inhibitors / Matthias Engel -- Retosiban and epelsiban: potent and selective orally available oxytocin antagonists / Alan D Borthwick, John Liddle -- Peptidic inhibitors of protein-protein interactions for cell adhesion receptors: RGD peptides and beyond / Carlos Mas-Moruno, Horst Kessler -- REPLACE strategy for generating non-ATP-competitive inhibitors of cell cycle protein kinases / Campbell McInnes -- Index. | |
| 520 | _aTreating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the devel. | ||
| 650 | 0 | _aProtein-protein interactions. | |
| 650 | 0 | _aProtein binding. | |
| 650 | 0 |
_aProteins _xInhibitors. |
|
| 650 | 4 | _aProtein binding. | |
| 650 | 4 | _aProtein-protein interactions. | |
| 650 | 4 |
_aProteins _xInhibitors. |
|
| 650 | 7 |
_aMEDICAL _xDrug Guides. _2bisacsh |
|
| 650 | 7 |
_aMEDICAL _xNursing _xPharmacology. _2bisacsh |
|
| 650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
|
| 650 | 7 |
_aMEDICAL _xPharmacy. _2bisacsh |
|
| 650 | 7 |
_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790 |
|
| 650 | 7 |
_aProtein-protein interactions. _2fast _0(OCoLC)fst01079705 |
|
| 655 | 4 | _aElectronic books. | |
| 700 | 1 | _aDömling, Alexander. | |
| 776 | 0 | 8 |
_iPrint version: _tProtein-protein interactions in drug discovery. _dWeinheim : Wiley-VCH Verlag GmbH, 2013 _z9783527331079 |
| 830 | 0 |
_aMethods and principles in medicinal chemistry ; _vv. 56. |
|
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527648207 _zWiley Online Library |
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