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003 | OCoLC | ||
005 | 20171224114056.0 | ||
006 | m o d | ||
007 | cr ||||||||||| | ||
008 | 121002s2013 nju ob 001 0 eng | ||
010 | _a 2012040270 | ||
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_aRM301.4 _b.F87 2013 |
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_a615.7 _223 |
049 | _aMAIN | ||
245 | 0 | 0 |
_aFusion protein technologies for biopharmaceuticals : _bapplications and challenges / _cedited by Stefan R. Schmidt. |
260 |
_aHoboken, New Jersey : _bJohn Wiley & Sons, _c©2013. |
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300 | _a1 online resource. | ||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
||
504 | _aIncludes bibliographical references and index. | ||
588 | 0 | _aPrint version record and CIP data provided by publisher. | |
505 | 0 | _apt. 1. Introduction -- pt. 2. The triple t paradigm : time, toxin, targeting -- pt. 3. Beyond the triple t-paradigm. | |
520 | _aThe state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs-with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protei. | ||
650 | 0 | _aBiopharmaceutics. | |
650 | 0 | _aPharmaceutical biotechnology. | |
650 | 4 | _aDrug carriers. | |
650 | 4 |
_aImmunotoxins _xTherapeutic use. |
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650 | 4 | _aProtein engineering. | |
650 | 4 |
_aRecombinant fusion proteins _xTherapeutic use. |
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650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
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650 | 7 |
_aBiopharmaceutics. _2fast _0(OCoLC)fst00832650 |
|
650 | 7 |
_aPharmaceutical biotechnology. _2fast _0(OCoLC)fst01060106 |
|
650 | 2 |
_aRecombinant Fusion Proteins _xtherapeutic use. |
|
650 | 2 | _aDrug Carriers. | |
650 | 2 |
_aImmunotoxins _xpharmacokinetics. |
|
650 | 2 |
_aImmunotoxins _xtherapeutic use. |
|
650 | 2 | _aProtein Engineering. | |
650 | 2 |
_aRecombinant Fusion Proteins _xpharmacokinetics. |
|
655 | 4 | _aElectronic books. | |
655 | 7 |
_aElectronic books. _2local |
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700 | 1 | _aSchmidt, Stefan R. | |
776 | 0 | 8 |
_iPrint version: _tFusion protein technologies for biopharmaceuticals. _dHoboken, N.J. : John Wiley & Sons, ©2013 _z9780470646274 _w(DLC) 2012039440 |
856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118354599 _zWiley Online Library |
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