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006 m o d
007 cr |n|---|||||
008 120521s2012 nju ob 001 0 eng d
040 _aEBLCP
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019 _a796087997
_a864910740
_a872697557
020 _a9781118310311
_q(electronic bk.)
020 _a1118310314
_q(electronic bk.)
020 _a9781118310298
_q(electronic bk.)
020 _a1118310292
_q(electronic bk.)
020 _a9781118310304
_q(electronic bk.)
020 _a1118310306
_q(electronic bk.)
020 _z9780470584927
_q(cloth)
020 _z0470584920
_q(cloth)
028 0 1 _aEB00063323
_bRecorded Books
029 1 _aAU@
_b000049595558
029 1 _aDEBBG
_bBV041049299
029 1 _aNZ1
_b14857436
029 1 _aZWZ
_b176959769
035 _a(OCoLC)793995949
_z(OCoLC)796087997
_z(OCoLC)864910740
_z(OCoLC)872697557
037 _a9CB1EADD-C87E-47D5-8E45-0D6294D5C400
_bOverDrive, Inc.
_nhttp://www.overdrive.com
050 4 _aRC262
_b.S49 2012
050 4 _aQZ200
060 4 _aQZ 200
072 7 _aMED
_x062000
_2bisacsh
082 0 4 _a616.99
_a616.9940564
049 _aMAIN
100 1 _aSeyfried, Thomas N.,
_d1946-
245 1 0 _aCancer as a metabolic disease :
_bon the origin, management, and prevention of cancer /
_cThomas Seyfried.
260 _aHoboken :
_bJohn Wiley & Sons,
_c2012.
300 _a1 online resource (472 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aCancer as a Metabolic Disease; Contents; Foreword; Preface; 1. Images of Cancer; How Cancer is Viewed; References; 2. Confusion Surrounds the Origin of Cancer; The Oncogenic Paradox; Hallmarks of Cancer; Reassessment; References; 3. Cancer Models; Problems with Some Cancer Models; Animal Charges as a Major Impediment to Cancer Research; Problems with Tumor Histological Classification; Personal Perspective on Cancer; References; 4. Energetics of Normal Cells and Cancer Cells; Metabolic Homeostasis; The Constancy of the D G'ATP; ATP Production in Normal Cells and Tumor Cells.
505 8 _aEnergy Production Through Glucose Fermentation; Glutaminolysis with or without Lactate Production; Transamination Reactions; TCA Cycle, Substrate-Level Phosphorylation; Cholesterol Synthesis and Hypoxia; Summary; References; 5. Respiratory Dysfunction in Cancer Cells; Normal Mitochondria; Morphological Defects in Tumor Cell Mitochondria; Proteomic Abnormalities in Tumor Cell Mitochondria; Lipidomic Abnormalities in Tumor Cell Mitochondria; Cardiolipin: A Mitochondrial-Specific Lipid; Cardiolipin and Abnormal Energy Metabolism in Tumor Cells.
505 8 _aComplicating Influence of the In Vitro Growth Environment on Cardiolipin Composition and Energy Metabolism; Mitochondrial Uncoupling and Cancer; Cancer Cell Heat Production and Uncoupled Mitochondria; Personal Perspective; Summary; References; 6. The Warburg Dispute; Sidney Weinhouse's Criticisms of the Warburg Theory; Alan Aisenberg's Criticisms of the Warburg Theory; Sidney Colowick's Assessment of the Aisenberg Monograph; Apples and Oranges; References; 7. Is Respiration Normal in Cancer Cells?; Pseudo-Respiration.
505 8 _aHow Strong is the Scientific Evidence Showing that Tumor Cells can Produce Energy Through OxPhos?; OxPhos Origin of ATP in Cancer Cells Reevaluated; What About OxPhos Expression in Other Tumors?; The Pedersen Review on Tumor Mitochondria and the Bioenergetics of Cancer Cells; References; 8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?; Amino Acid Fermentation can Maintain Cellular Energy Homeostasis During Anoxia; Evidence Suggesting that Metastatic Mouse Cells Derive Energy from Glutamine Fermentation.
505 8 _aFermentation Energy Pathways can Drive Cancer Cell Viability Under Hypoxia; Competing Explanations for the Metabolic Origin of Cancer; Chapter Summary; References; 9. Genes, Respiration, Viruses, and Cancer; Does Cancer have a Genetic Origin?; Respiratory Insufficiency as the Origin of Cancer; Germline Mutations, Damaged Respiration, and Cancer; Somatic Mutations and Cancer; Revisiting the Oncogene Theory; Mitochondrial Mutations and the Absence or Presence of Cancer; Viral Infection, Damaged Respiration, and the Origin of Cancer; Summary; References.
505 8 _a10. Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer.
520 _aThe book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.
588 0 _aPrint version record.
650 0 _aCancer
_xPrevention.
650 2 _aNeoplasms
_xdiet therapy.
650 2 _aNeoplasms
_xmetabolism.
650 2 _aEnergy Metabolism.
650 2 _aKetogenic Diet.
650 2 _aMitochondria
_xmetabolism.
650 4 _aMedicine.
650 7 _aMEDICAL
_xOncology.
_2bisacsh
650 7 _aCancer
_xPrevention.
_2fast
_0(OCoLC)fst00845452
655 4 _aElectronic books.
776 0 8 _iPrint version:
_aSeyfried, Thomas N., 1946-
_tCancer as a Metabolic Disease : On the Origin, Management, and Prevention of Cancer.
_dHoboken : John Wiley & Sons, ©2012
_z9780470584927
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118310311
_zWiley Online Library
938 _aEBL - Ebook Library
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_nEBL861782
938 _aEBSCOhost
_bEBSC
_n518534
938 _aRecorded Books, LLC
_bRECE
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938 _aYBP Library Services
_bYANK
_n7293117
938 _aYBP Library Services
_bYANK
_n7643983
938 _aYBP Library Services
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999 _c11933
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