000			08166cam a2200841Mi 4500
001			ocn746598445
003			OCoLC
005			20171224113710.0
006			m o d
007			cr |n|||||||||
008			100616s2011 njua ob 001 0 eng d
010			_z 2010025372
040			_aCDX _beng _erda _epn _cCDX _dTXA _dYDXCP _dE7B _dN$T _dEBLCP _dOCLCQ _dOCLCF _dOCLCQ _dNLGGC _dOCLCQ _dMHW _dUKDOC _dAU@ _dOCLCQ _dTMC _dOCLCQ _dOCLCO _dOCL _dDEBBG _dD6H _dAZK
019			_a758982153 _a770872450 _a842264613 _a961519634 _a962640546
020			_a9780470929353 _q(electronic bk.)
020			_a0470929359 _q(electronic bk.)
020			_a9780470929346 _q(electronic bk.)
020			_a0470929340 _q(electronic bk.)
020			_z9780470455630 _q(Cloth)
020			_z0470455632 _q(Cloth)
020			_z9780470934685
020			_z0470934689
024	8		_a9786613203632
029	1		_aAU@ _b000047773982
029	1		_aAU@ _b000050894470
029	1		_aDKDLA _b820120-katalog:000573080
029	1		_aNZ1 _b15915097
029	1		_aDEBBG _bBV043393434
035			_a(OCoLC)746598445 _z(OCoLC)758982153 _z(OCoLC)770872450 _z(OCoLC)842264613 _z(OCoLC)961519634 _z(OCoLC)962640546
037			_a320363 _bMIL
050		4	_aRM411 _b.A5753 2011eb
060		4	_aQV 268.5 _bA63347 2011
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615/.7924 _222
049			_aMAIN
245	0	0	_aAntiviral drugs : _bfrom basic discovery through clinical trials / _cedited by Wieslaw M. Kazmierski.
264		1	_aHoboken, N.J. : _bWiley, _c©2011.
300			_a1 online resource (xiii, 438 pages) : _billustrations (some color)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
380			_aBibliography
504			_aIncludes bibliographical references and index.
505	0		_aFrontmatter -- Color Plates -- Human Immunodeficiency Virus. Discovery and Development of Atazanavir / Awny Farajallah, R Todd Bunch, Nicholas A Meanwell -- Discovery and Development of PL-100, A Novel HIV-1 Protease Inhibitor / Jinzi J Wu, Joseph Musto -- Darunavir (Prezista, TMC114): From Bench to Clinic, Improving Treatment Options for HIV-Infected Patients / Marie-Pierre de B̌thune, Vanitha Sekar, Sabrina Spinosa-Guzman, Marc Vanstockem, Sandra De Meyer, Piet Wigerinck, Eric Lefebvre -- Discovery and Development of Tipranavir / Karen R Romines -- TMC278 (Rilpivirine): A Next-Generation NNRTI in Phase III Clinical Development for Treatment-Naive Patients / Jerome Guillemont, Katia Boven, Herta Crauwels, Marie-Pierre de B̌thune -- Etravirine: From TMC125 to Intelence: A Treatment Paradigm Shift for HIV-Infected Patients / Koen Andries, Ann Debunne, Thomas N Kakuda, Michael Kukla, Ruud Leemans, Johan Vingerhoets, Brian Woodfall, Marie-Pierre de B̌thune -- Discovery and Development of Tenofovir Disoproxil Fumarate / Erik De Clercq -- Discovery and Development of Apricitabine / Susan Cox, John Deadman, Justine Southby, Jonathan Coates -- Discovery and Development of Maraviroc and PF-232798: CCR5 Antagonists for the Treatment of HIV-1 Infection / Patrick Dorr, Paul Stupple -- Discovery of the CCR5 Antagonist Vicriviroc (Sch 417690/Sch-D) for the Treatment of HIV-1 Infection / Jayaram R Tagat, Julie M Strizki, Lisa M Dunkle -- Discovery and Development of HIV-1 Entry Inhibitors That Target gp120 / John F Kadow, John Bender, Alicia Regueiro-Ren, Yasutsugu Ueda, Tao Wang, Kap-Sun Yeung, Nicholas A Meanwell -- Discovery of MK-0536: A Potential Second-Generation HIV-1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation / Melissa S Egbertson, John S Wai, Mark Cameron, R Scott Hoerrner -- Discovery and Development of HIV Integrase Inhibitor Raltegravir / Vincenzo Summa, Paola Pace -- Elvitegravir: A Novel Monoketo Acid HIV-1 Integrase Strand Transfer Inhibitor / Hisashi Shinkai, Masanori Sato, Yuji Matsuzaki -- Hepatitis C Virus. Discovery and Development of Telaprevir / Anne-Laure Grillot, Luc J Farmer, B Govinda Rao, William P Taylor, Ilan S Weisberg, Ira M Jacobson, Robert B Perni, Ann D Kwong -- Discovery and Development of BILN 2061 and Follow-Up BI 201335 / Montse Llin̉s-Brunet, Peter W White -- Intervention of Hepatitis C Replication through NS3-4A, the Protease Inhibitor Boceprevir / Srikanth Venkatraman, F George Njoroge -- Discovery and Development of the HCV NS3/4A Protease Inhibitor Danoprevir (ITMN-191/RG7227) / Scott D Seiwert, Karl Kossen, Lin Pan, Jyanwei Liu, Brad O Buckman -- Discovery and Development of the HCV Protease Inhibitor TMC435 / Pierre Raboisson, Gregory Fanning, Herman de Kock, Asa Rosenquist, Rene Verloes, Kenneth Simmen -- Discovery and Clinical Evaluation of the Nucleoside Analog Balapiravir (R1626) for the Treatment of HCV Infection / Klaus Klumpp, David B Smith -- Discovery and Development of PSI-6130/RG7128 / Phillip A Furman, Michael J Otto, Michael J Sofia -- Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV / Kai Lin -- HCV Viral Entry Inhibitors / Flossie Wong-Staal, Guohong Liu, Jeffrey McKelvy -- Respiratory Syncytial Virus Inhibitors. Discovery of the RSV Inhibitor TMC353121 / Jean-Fraṅois Bonfanti, Gabriela Ispas, Frans Van Velsen, Wieslawa Olszewska, Tom Gevers, Dirk Roymans -- Discovery and Development of Orally Active RSV Fusion Inhibitors / Nicholas A Meanwell, Christopher W Cianci, Mark R Krystal -- Discovery and Development of RSV604 / Joanna Chapman, Stuart Cockerill -- Influenza, Hepatitis B, and Cytomegalovirus Inhibitors. Discovery and Development of Influenza Virus Sialidase Inhibitor Relenza / Robin Thomson, Mark von Itzstein -- Discovery and Development of Entecavir / Richard Wilber, Bruce Kreter, Marc Bifano, Stephanie Danetz, Lois Lehman-McKeeman, Daniel J Tenney, Nicholas Meanwell, Robert Zahler, Helena Brett-Smith -- Benzimidazole Ribonucleosides: Novel Drug Candidates for the Prevention and Treatment of Cytomegalovirus Diseases / Karen K Biron, Kristjan S Gudmundsson, John C Drach -- Index.
520			_aThis book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.
588	0		_aPrint version record.
650		0	_aAntiviral agents.
650		0	_aClinical trials.
650		4	_aAntiviral Agents _xtherapeutic use.
650		4	_aAntiviral agents.
650		4	_aDrug Evaluation.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aClinical trials _2fast _0(OCoLC)fst00864429
650		7	_aAntiviral agents. _2fast _0(OCoLC)fst00810869
650		2	_aAntiviral Agents _xtherapeutic use.
650		2	_aClinical Trials as Topic.
650		2	_aDrug Discovery.
650		2	_aDrug Evaluation.
655		4	_aElectronic books.
700	1		_aKazmierski, Wieslaw M.
776	0	8	_iPrint version: _z9786613203632 _w(DLC) 2010025372
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9780470929353 _zWiley Online Library
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