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019 _a740225701
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_a778454561
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020 _a9783527635955
_q(electronic bk.)
020 _a3527635955
_q(electronic bk.)
020 _a9783527635979
_q(electronic bk.)
020 _a3527635971
_q(electronic bk.)
020 _a1283140918
020 _a9781283140911
020 _z9783527326969
_q(hbk.)
020 _z3527326960
_q(hbk.)
020 _z9783527635962
020 _z3527635963
020 _z9783527635986
020 _z352763598X
024 8 _a9786613140913
029 1 _aAU@
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029 1 _aNZ1
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029 1 _aNZ1
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035 _a(OCoLC)729726279
_z(OCoLC)740225701
_z(OCoLC)741454003
_z(OCoLC)778454561
_z(OCoLC)781264224
_z(OCoLC)785512762
_z(OCoLC)816845214
037 _a10.1002/9783527635955
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
050 4 _aRS431.A66
_bA68 2011
060 4 _aQV268.5
072 7 _aMED
_x071000
_2bisacsh
082 0 4 _a615.7924
_222
049 _aMAIN
245 0 0 _aAntiviral drug strategies /
_cedited by Erik De Clercq.
264 1 _aWeinheim :
_bWiley-VCH ;
_aChichester :
_bJohn Wiley [distributor],
_c2011.
300 _a1 online resource (xx, 406 pages) :
_billustrations (some color).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aMethods and principles in medicinal chemistry ;
_vv. 50
504 _aIncludes bibliographical references and index.
505 0 0 _tOutlook of the antiviral drug era, now more than 50 years after description of the first antiviral drug /
_rErik De Clercq --
_tInhibition of HIV entry /
_rJosé A. Esté --
_tTargeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors /
_rArnout R.D. Voet,
_rMarc De Maeyer,
_rFrauke Christ,
_rZeger Debyser --
_tFrom saquinavir to darunavir: the impact of 10 years of medicinal chemistry on a lethal disease /
_rMarie-Pierre de Béthune,
_rAnik Peeters,
_rPiet Wigerinck --
_tAcyclic and cyclic nucleoside phosphonates /
_rRichard L. Mackman,
_rTomas Cihlar --
_tHelicase-primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus /
_rSubhajit Biswas,
_rHugh J. Field --
_tCyclophilin inhibitors /
_rGrégoire Vuagniaux,
_rArnaud Hamel,
_rRafael Crabbé,
_rHervé C. Porchet,
_rJean-Maurice Dumont --
_tAlkoxyalkyl ester prodrugs of antiviral nucleoside phosphates and phosphonates /
_rJames R. Beadle,
_rKarl Y. Hostetler --
_tMaribavir: a novel benzimidazole ribonucleoside for the prevention and treatment of cytomegalovirus diseases /
_rKaren K. Biron --
_tAnti-HCMV compounds /
_rGraciela Andrei,
_rRobert Snoeck --
_tLethal mutagenesis as an unconventional approach to combat HIV /
_rPinar Iyidogan,
_rKaren S. Anderson --
_tRecent progress in the development of HCV protease inhibitors /
_rNagraj Mani,
_rBhisetti G. Rao,
_rTara L. Kieffer,
_rAnn D. Kwong --
_tAntiviral RNAi: how to silence viruses /
_rKarin J. von Eije,
_rBen Berkhout --
_tNeuraminidase inhibitors as anti-influenza agents /
_rWillard Lew,
_rMichael Z. Wang,
_rXiaowu Chen,
_rJames F. Rooney,
_rChoung Kim --
_tFrom TIBO to rilpivirine: the chronicle of the discovery of the ideal nonnucleoside reverse transcriptase inhibitor /
_rErik De Clercq.
588 0 _aPrint version record.
520 _aBy focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de.
650 0 _aAntiviral agents
_xDevelopment.
650 4 _aAntiviral agents
_xDevelopment.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 2 _aAntiviral Agents.
650 2 _aDrug Discovery.
655 4 _aElectronic books.
700 1 _aDe Clercq, Erik.
776 0 8 _iPrint version:
_tAntiviral drug strategies.
_dWeinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011
_z9783527326969
_w(OCoLC)664325845
830 0 _aMethods and principles in medicinal chemistry ;
_vv. 50.
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527635955
_zWiley Online Library
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