Bioactive Natural Products : (Record no. 13872)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06024cam a2200733Ii 4500 |
| 001 - CONTROL NUMBER | |
| control field | ocn900723990 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20171224114824.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150126s2015 gw ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | N$T |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | N$T |
| Modifying agency | IDEBK |
| -- | N$T |
| -- | E7B |
| -- | YDXCP |
| -- | COO |
| -- | RECBK |
| -- | OCLCF |
| -- | CUS |
| -- | EBLCP |
| -- | DEBSZ |
| -- | UIU |
| -- | DEBBG |
| -- | CCO |
| 066 ## - CHARACTER SETS PRESENT | |
| Alternate G0 or G1 character set | (S |
| 019 ## - | |
| -- | 902417600 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527684410 |
| Qualifying information | electronic bk. |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527684417 |
| Qualifying information | electronic bk. |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527684403 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527684409 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 9783527337941 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 3527337946 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781322776422 |
| Qualifying information | MyiLibrary |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 1322776423 |
| Qualifying information | MyiLibrary |
| 029 1# - (OCLC) | |
| OCLC library identifier | DEBSZ |
| System control number | 43187512X |
| 029 1# - (OCLC) | |
| OCLC library identifier | DEBBG |
| System control number | BV043397474 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)900723990 |
| Canceled/invalid control number | (OCoLC)902417600 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QD415 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI |
| Subject category code subdivision | 013040 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547/.7 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 245 00 - TITLE STATEMENT | |
| Title | Bioactive Natural Products : |
| Remainder of title | Chemistry and Biology / |
| Statement of responsibility, etc | edited by Goutam Brahmachari. |
| 264 #1 - | |
| -- | Weinheim, Germany : |
| -- | Wiley-VCH, |
| -- | 2015. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xxxiv, 507 pages) |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 588 0# - | |
| -- | Vendor-supplied metadata. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Bioactive Natural Products; Contents; Foreword; Preface; About the Editor; List of Contributors; Chapter 1 An Overview; 1.1 Introduction; 1.2 An Overview of the Book; 1.2.1 Chapter 2; 1.2.2 Chapter 3; 1.2.3 Chapter 4; 1.2.4 Chapter 5; 1.2.5 Chapter 6; 1.2.6 Chapter 7; 1.2.7 Chapter 8; 1.2.8 Chapter 9; 1.2.9 Chapter 10; 1.2.10 Chapter 11; 1.2.11 Chapter 12; 1.2.12 Chapter 13; 1.2.13 Chapter 14; 1.2.14 Chapter 15; 1.2.15 Chapter 16; 1.2.16 Chapter 17; 1.3 Concluding Remarks; Chapter 2 Use of Chemical Genomics to Investigate the Mechanism of Action for Inhibitory Bioactive Natural Compounds. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2.1 Introduction: Antibiotic Resistance and the Use of Natural Products as a Source for Novel Antimicrobials2.2 Chemical Genetics and Genomics; 2.3 Development of GDA Technology; 2.3.1 The Use of Gene Deletion Arrays (GDAs) to Investigate MOA; 2.3.2 Chemical Genetic Interactions; 2.3.3 Quantifying Genetic and Chemical Genetic Interactions; 2.3.4 Data Analysis; 2.3.5 Platforms for Chemical Genomic GDA Studies; 2.3.6 Why Screen Natural Products in GDAs?; 2.3.7 Successful Applications of GDA Technology; 2.4 Concluding Remarks; Abbreviations; References. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Linkage | 880-01 |
| Formatted contents note | Chapter 4 Immunosuppressants: Remarkable Microbial Products4.1 Introduction; 4.2 Discovery; 4.3 Mode of Action; 4.4 Biosynthesis; 4.4.1 Acetate, Propionate, Butyrate, Methionine, and Valine as Precursors of the Macrolide Rings of Sirolimus, Ascomycin, and Tacrolimus; 4.4.2 Pipecolate Moiety of the Macrolide Ring of Sirolimus, Ascomycin, and Tacrolimus; 4.4.3 The Final Step in Biosynthesis of Ascomycins and Tacrolimus; 4.4.4 Formation of the Substituted Cyclohexyl Moiety of Sirolimus, Tacrolimus, and Ascomycins; 4.4.5 Biosynthesis of Cyclosporin; 4.5 Genetics and Strain Improvement. |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4.6 Fermentation and Nutritional Studies4.7 Other Activities of Immunosuppressants; 4.8 Concluding Remarks; Acknowledgments; References; Chapter 5 Activators and Inhibitors of ADAM-10 for Management of Cancer and Alzheimer's Disease; 5.1 Introduction to ADAM Family of Enzymes; 5.2 ADAM-10 Structure and Physiological Roles; 5.3 Pathological Significance; 5.3.1 Modulating ADAM Activity in Neurodegeneration; 5.3.2 ADAM-10 in Cancer Pathology; 5.4 ADAM-10 as Potential Drug Target; 5.5 Synthetic Inhibitors of ADAM-10; 5.6 Natural Products as Activators and Inhibitors for ADAM-10. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural productsFeatures chemi. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Natural products. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | SCIENCE / Chemistry / Organic |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| Source of heading or term | fast |
| -- | (OCoLC)fst00831961 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Natural products. |
| Source of heading or term | fast |
| -- | (OCoLC)fst01034390 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 655 #0 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brahmachari, Goutam, |
| Relator term | editor. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| Main entry heading | Brahmachari, Goutam. |
| Title | Bioactive Natural Products : Chemistry and Biology. |
| Place, publisher, and date of publication | Hoboken : Wiley, ©2015 |
| International Standard Book Number | 9783527337941 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://onlinelibrary.wiley.com/book/10.1002/9783527684403 |
| Public note | Wiley Online Library |
| 880 8# - ALTERNATE GRAPHIC REPRESENTATION | |
| Linkage | 505-01/(S |
| a | Chapter 3 High-Throughput Drug Screening Based on Cancer Signaling in Natural Product Screening3.1 Introduction; 3.2 Cancer Signaling Pathways with Their Own Drug Screening Assays in HTS; 3.2.1 β-Galactosidase Enzyme Complementation Assays for EGFR Signaling Drug Screening; 3.2.2 Fluorescence Superquenching Assays for PI3Ks Signaling Drug Screening; 3.2.3 TOP Flash Reporter Gene Assays for Wnt Signaling Drug Screening; 3.2.4 Luciferase Reporter Gene Assays for STATs Signaling Drug Screening; 3.3 Concluding Remarks; Abbreviations; References. |
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