Thermodynamics and kinetics of drug binding /
edited by György M. Keserü and David C. Swinney.
- 1 online resource (xxiii, 334 pages) : illustrations (some color)
- Methods and principles in medicinal chemistry ; volume 65 .
- Methods and principles in medicinal chemistry ; v. 65. .
Includes bibliographical references and index.
"This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."--
9783527673049 3527673040 9783527673025 3527673024 9783527673032 3527673032
10.1002/9783527673025 doi
Drug development.
Binding sites (Biochemistry)--Thermodynamics.
Pharmacokinetics.
MEDICAL / Pharmacology
Binding sites (Biochemistry)--Thermodynamics.
Drug development.
Pharmacokinetics.
Drug Discovery.
Receptors, Drug.
Ligands.
Thermodynamics.
Pharmacokinetics.
Electronic books.
Electronic books.
RM301.25 / .T44 2015eb
615.19
W1 / ME9613h v.65 2015 QV 745
Includes bibliographical references and index.
"This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."--
9783527673049 3527673040 9783527673025 3527673024 9783527673032 3527673032
10.1002/9783527673025 doi
Drug development.
Binding sites (Biochemistry)--Thermodynamics.
Pharmacokinetics.
MEDICAL / Pharmacology
Binding sites (Biochemistry)--Thermodynamics.
Drug development.
Pharmacokinetics.
Drug Discovery.
Receptors, Drug.
Ligands.
Thermodynamics.
Pharmacokinetics.
Electronic books.
Electronic books.
RM301.25 / .T44 2015eb
615.19
W1 / ME9613h v.65 2015 QV 745